Adam Gazzaley, MD, PhD

Adam Gazzaley, MD, PhD
MD and PhD, Mount Sinai School of Medicine, New York
Professor of Neurology, Physiology and Psychiatry

Phone: (415) 476-2162
Fax: (415) 514-4451
Email: [email protected]

UCSF Profiles

Gazzaley Lab

Research Interests

My laboratory studies neural mechanisms of perception, attention and memory, with an emphasis on the impact of distraction and multitasking on these abilities. Our research approach utilizes a powerful combination of human neurophysiological tools, including functional magnetic resonance imaging (fMRI), electroencephalography (EEG) and transcranial electrical and magnetic stimulation (TMS, TES). A major focus of our research has been to expand our understanding of alterations in the aging brain that lead to cognitive decline. Our most recent studies explore how we may enhance our cognitive abilities via engagement with custom designed video games, neurofeedback and TES. We are currently studying the neurocognitive effects of a meditation training app we developed, which makes the goals of the training quantifiable and attainable. I have enthusiastically worked with Dr. Weng in developing this K award proposal and have provided scanner, computing, and personnel resources from my lab. I am committed to serving as Dr. Weng’s primary mentor during the K award, and bring to this role a strong background in the neuroscience of cognitive training and quantifying cognitive training with mobile apps.

Professional Honors and Awards

  • Krieg Cortical Kudos- Cortical Scholar Award 1998 Mount Sinai - Basic Science Achievement Award 1998 Morris Bender Award in Clinical Neurology
  • NIH Career Development Award
  • Laird Cermak Award
  • Pfizer/AFAR Innovations in Aging Award
  • Ellison Foundation New Scholar Award in Aging
  • UCSF Postdoctoral Association Outstanding Mentorship Award
  • Harold Brenner Pepinsky Early Career Award in Neurobehavioral Science 2015 UCSF 150th Anniversary Alumni Excellence Award
  • Elected Membership in American Society for Clinical Investigation 2015 Society for Neuroscience – Science Educator Award

Selected Publications

  1. Gazzaley, A., Siegel, S.J., Kordower, J.H., Mufson, E.J. and Morrison, J.H. Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys. Proceedings of the National Academy of Science USA 93(7): 3121-5 (1996)
  2. Gazzaley, A., Weiland, N.G., McEwen, B.S. and Morrison, J.H. Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus. Journal of Neuroscience 16(21): 6830-8 (1996)
  3. Gazzaley, A., Benson, D.L., Huntley, G.W. and Morrison, J.H. Differential subcellular regulation of NMDAR1 protein and mRNA in dendrites of dentate gyrus granule cells after perforant path transection. Journal of Neuroscience 17(6): 2006-17 (1997)
  4. Gazzaley, A., Cooney, J.W., Rissman, J., D’Esposito, M. Top-down suppression deficit underlies working memory impairment in normal aging. Nature Neuroscience 8(10), 1298-1300. (2005)
  5. Gazzaley, A., Clapp, W., Kelley, J., McEvoy, K., Knight, R., D’Esposito, M. Age-related top-down suppression deficit in the early stages of cortical visual memory processing. Proceedings of the National Academy of Science USA 105(35): 13122-13126. (2008) PMCID: PMC2529045
  6. Clapp, W., Rubens, M. & Gazzaley, A. A deficit in switching between functional brain networks underlies the impact of multitasking on working memory in older adults. Proceedings of the National Academy of Science USA 108: 7212–7217(2011) PMCID: PMC3084135
  7. Chadick, Z., Zanto, T., Gazzaley, A., Structural and functional differences in medial prefrontal cortex underlie distractibility and suppression deficits in ageing. Nature Communications 5(4223): 1- 12 (2014) PMID: 24979364 PMCID: PMC4088291
  8. Clapp, W., Rubens, M.T., Gazzaley, A. Mechanisms of working memory disruption by external interference. Cerebral Cortex 20(4): 859-72 (2010) PMCID: PMC2837090
  9. Wais, P., Rubens, M., Boccanfuso, J. & Gazzaley, A. Neural Mechanisms Underlying the Impact of Visual Distraction on Long-Term Memory Retrieval. Journal of Neuroscience (2010) PMCID: PMC2919837
  10. Zanto, T., Rubens, M., Thangavel, A. & Gazzaley, A. A causal role of the prefrontal cortex in top- down modulation of early visual processing and working memory. Nature Neuroscience 14: 656- 661 (2011) PMCID: PMC3083493
  11. Chadick, J.Z. & Gazzaley, A. Differential coupling of visual cortical areas with the default network or frontal-parietal network based on task goals. Nature Neuroscience 14: 830-2 (2011) PMCID: PMC3125492
  12. Berry, A., Zanto, P. Clapp, W., Hardy, J., Delahunt, P., Mahncke, H. and Gazzaley, A. The Influence of Perceptual Training on Working Memory in Older Adults PLoS ONE 5(7): e11537. doi:10.1371/journal.pone.0011537 (2010) PMCID: PMC2904363
  13. Anguera, Boccanfuso, Rintoul, Al-Hashimi, Faraji, Janowich, Kong, Larraburo, Rolle, Johnston, Gazzaley. Video game multitasking training enhances cognitive control in older adults. Nature 501: 97-101 (2013) PMCID: PMC3983066
  14. Mishra, J., de Villers-Sidani, E., Merzenich, M., Gazzaley, A. Adaptive Training Diminishes Distractibility in Aging across Species. Neuron 84: 1091-1103 (2014) PMCID: PMC4264379
  15. Mishra J, Gazzaley A. Closed Loop Rehabilitation of Age-related Cognitive Disorders. Seminars in Neurology 34: 584-590. (2014) PMID: 25520029 [PubMed - in process]