Daniel H. Mathalon, MD, PhD

Daniel Mathalon, MD, PhD
MD, Stanford University
PhD, Indiana University, Bloomington
Professor, Department of Psychiatry, UCSF
Phone: (415) 221-4810 (ext. 3860)
Email: [email protected]

UCSF Profiles

Brain Imaging and EEG Laboratory

Research Interests:

I am a psychiatrist and psychologist by training, with extensive experience with electroencephalographic and functional magnetic resonance imaging methods and their application to the study of neuropsychiatric disorders. My lab has focused on studies of schizophrenia, including the prodromal period preceding psychosis onset, and is aiming to identify and validate brain biomarkers that can serve as predictors of psychosis risk in clinical high risk patients. These biomarkers are elicited by paradigms that study highly translational domains of brain function, including auditory stimulus processing and predictive coding in the auditory system, visual cortical plasticity, and working memory. I have been a mentor for a number of trainees who have learned electrophysiological and neuroimaging methods during fellowships in my lab. I have also served as a mentor or co-mentor on a number of career development awards for junior faculty launching their careers.

Professional Honors and Awards:

  • 1983 A.B. summa cum laude and highest departmental honors; Departmental Citation in Psychology, UC Berkeley; Phi Beta Kappa; Psi Chi (Psychology honorary)
  • 1986 Ph.D. Qualifying Exam Commendations; Edwards Fellowship, Indiana University 1989 Member, Sigma Xi
  • 1997 Young Investigator Travel Award, International Congress on Schizophrenia Research
  • 1998 Laughlin Fellowship, American College of Psychiatrists; Lilly Travel Award, Society of Biological Psychiatry; APA Lilly Resident Research Award; APA Junior Investigator Research Colloquium
  • 1999 Bristol-Myers Squibb Travel Fellowship, ACNP
  • 2003 Early Career Contribution Award, EEG Clinical Neuroscience Society 2004 & 2006 Senior Scientist Award, Biennial Winter Workshop on Schizophrenia
  • 2005 Kempf Award, American Psychiatric Association
  • 2014 One of 10 Major Discoveries in 2014 by NARSAD Grantees List, Brain & Behavior Research Foundation.

Selected Publications:

  1. Mathalon DH, Ford JM, Rosenbloom M, Pfefferbaum A. P300 reduction and prolongation with illness duration in schizophrenia. Biol Psychiatry. 2000 Mar 1;47(5):413-27. Erratum in: Biol Psychiatry 2000 Jun 15;47(12):1091. PMID: 10704953
  2. Mathalon DH, Ford JM, Pfefferbaum A. Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study. Biol Psychiatry. 2000 Mar 1;47(5):434-49. PMID: 10704955.
  3. Watson TD, Petrakis IL, Edgecombe J, Perrino A, Krystal JH, Mathalon DH. Modulation of the cortical processing of novel and target stimuli by drugs affecting glutamate and GABA neurotransmission. Int J Neuropsychopharmacol. 2009 Apr;12(3):357-70. doi: 10.1017/S1461145708009334. Epub 2008 Sep 4. PMID: 18771605; PMCID: PMC2900256.
  4. Mathalon DH, Hoffman RE, Watson TD, Miller RM, Roach BJ, Ford JM. Neurophysiological Distinction between Schizophrenia and Schizoaffective Disorder. Front Hum Neurosci. 2010 Jan 29;3:70. doi: 10.3389/neuro.09.070.2009. eCollection 2010. PMID: 20140266; PMCID: PMC2816168.
  5. Mathalon DH, Fedor M, Faustman WO, Gray M, Askari N, Ford JM. Response-monitoring dysfunction in schizophrenia: an event-related brain potential study. J Abnorm Psychol. 2002 Feb;111(1):22-41. PMID: 11866176.
  6. Mathalon DH, Bennett A, Askari N, Gray EM, Rosenbloom MJ, Ford JM. Response-monitoring dysfunction in aging and Alzheimer's disease: an event-related potential study. Neurobiol Aging. 2003 Sep;24(5):675-85. PMID: 12885575.
  7. Mathalon DH, Jorgensen KW, Roach BJ, Ford JM. Error detection failures in schizophrenia: ERPs and FMRI. Int J Psychophysiol. 2009 Aug;73(2):109-17. doi: 10.1016/j.ijpsycho.2009.02.005. Epub 2009 May 3. PMID: 19414043; PMCID: PMC4005823.
  8. Perez VB, Ford JM, Roach BJ, Woods SW, McGlashan TH, Srihari VH, Loewy RL, Vinogradov S, Mathalon DH. Error monitoring dysfunction across the illness course of schizophrenia. J Abnorm Psychol. 2012 May;121(2):372-87. doi: 10.1037/a0025487. Epub 2011 Nov 7. PMID: 22060947; PMCID: PMC3358508.
  9. Perez VB, Roach BJ, Woods SW, Srihari VH, McGlashan TH, Ford JM, Mathalon DH. Early auditory gamma-band responses in patients at clinical high risk for schizophrenia. Suppl Clin Neurophysiol. 2013;62:147-62. PMID: 24053038; PMCID: PMC4120874.
  10. Perez VB, Woods SW, Roach BJ, Ford JM, McGlashan TH, Srihari VH, Mathalon DH. Automatic auditory processing deficits in schizophrenia and clinical high-risk patients: forecasting psychosis risk with mismatch negativity. Biol Psychiatry. 2014 Mar 15;75(6):459-69. doi: 10.1016/j.biopsych.2013.07.038. Epub 2013 Sep 16. PMID: 24050720; PMCID: PMC4028131.
  11. Fryer SL, Woods SW, Kiehl KA, Calhoun VD, Pearlson GD, Roach BJ, Ford JM, Srihari VH, McGlashan TH, Mathalon DH. Deficient Suppression of Default Mode Regions during Working Memory in Individuals with Early Psychosis and at Clinical High-Risk for Psychosis. Front Psychiatry. 2013 Sep 10;4:92. doi: 10.3389/fpsyt.2013.00092. eCollection 2013. PMID: 24032017; PMCID: PMC3768116.
  12. Cannon TD, Chung Y, He G, Sun D, Jacobson A, van Erp TG, McEwen S, Addington J, Bearden CE, Cadenhead K, Cornblatt B, Mathalon DH, McGlashan T, Perkins D, Jeffries C, Seidman LJ, Tsuang M, Walker E, Woods SW, Heinssen R; North American Prodrome Longitudinal Study Consortium. Progressive reduction in cortical thickness as psychosis develops: a multisite longitudinal neuroimaging study of youth at elevated clinical risk. Biol Psychiatry. 2015 Jan 15;77(2):147-57. doi: 10.1016/j.biopsych.2014.05.023. Epub 2014 Jun 12. PMID: 25034946; PMCID: PMC4264996.
  13. Ford JM, Mathalon DH, Kalba S, Whitfield S, Faustman WO, Roth WT. Cortical responsiveness during talking and listening in schizophrenia: an event-related brain potential study. Biol Psychiatry. 2001 Oct 1;50(7):540-9. PMID: 11600107.
  14. Ford JM, Gray M, Faustman WO, Roach BJ, Mathalon DH. Dissecting corollary discharge dysfunction in schizophrenia. Psychophysiology. 2007 Jul;44(4):522-9. PMID: 17565658.
  15. Ford JM, Roach BJ, Faustman WO, Mathalon DH. Synch before you speak: auditory hallucinations in schizophrenia. Am J Psychiatry. 2007 Mar;164(3):458-66. PMID: 17329471.
  16. Heinks-Maldonado TH, Mathalon DH, Houde JF, Gray M, Faustman WO, Ford JM. Relationship of imprecise corollary discharge in schizophrenia to auditory hallucinations. Arch Gen Psychiatry. 2007 Mar;64(3):286-96. PMID: 17339517.
  17. Mathalon DH, Sullivan EV, Lim KO, Pfefferbaum A. Progressive brain volume changes and the clinical course of schizophrenia in men: a longitudinal magnetic resonance imaging study. Arch Gen Psychiatry. 2001 Feb;58(2):148-57. PMID: 11177116.
  18. Mathalon DH, Pfefferbaum A, Lim KO, Rosenbloom MJ, Sullivan EV. Compounded brain volume deficits in schizophrenia-alcoholism comorbidity. Arch Gen Psychiatry. 2003 Mar;60(3):245-52. PMID: 12622657.
  19. Yun RJ, Krystal JH, Mathalon DH. Working memory overload: fronto-limbic interactions and effects on subsequent working memory function. Brain Imaging Behav. 2010 Mar;4(1):96-108. doi: 10.1007/s11682- 010-9089-9. PMID: 20503117; PMCID: PMC2854358.
  20. Fryer SL, Jorgensen KW, Yetter EJ, Daurignac EC, Watson TD, Shanbhag H, Krystal JH, Mathalon DH. Differential brain response to alcohol cue distractors across stages of alcohol dependence. Biol Psychol. 2013 Feb;92(2):282-91. doi: 10.1016/j.biopsycho.2012.10.004. Epub 2012 Nov 3. PMID: 23131612; PMCID: PMC3947923