Robin Carhart-Harris, PhD

Robin Carhart-Harris
Professor in Residence
M_Neurology

Dr. Carhart-Harris’s research focuses on the neurobiology of consciousness and the therapeutic potential of psychedelic compounds for mental health disorders. He investigates the brain mechanisms underlying substances such as psilocybin, LSD, MDMA, and DMT using multimodal neuroimaging and clinical trials, with a particular emphasis on treatment-resistant depression and other severe psychiatric conditions. His work integrates experimental medicine, computational models, and novel trial designs to advance understanding of how psychedelics alter brain function and to develop innovative, transdiagnostic treatment approaches in psychiatry.

Publications

"Awe-scillations": EEG spectral and complexity representations of awe.

bioRxiv : the preprint server for biology

Chen JC, Mace G, Ostrand A, Valtierra C, Griffith S, Campusano R, Li A, Vinson E, Schlomberg JT, Eshel M, Suntay JM, Rahim S, Anguera R, Brown DA, Swann NC, Mazzucato L, Hu X, Zhang D, Timmermann C, Carhart-Harris RL, Zanto T, Ziegler D, Gazzaley A, Pasquini L

Efficacy, all-cause discontinuation, and safety of serotonergic psychedelics and MDMA to treat mental disorders: A living systematic review with meta-analysis.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

Højlund M, Kafali HY, Kirmizi B, Fusar-Poli P, Correll CU, Cortese S, Sabé M, Fiedorowicz J, Saraf G, Zein J, Berk M, Husain MI, Rosenblat JD, Rubaiyat R, Corace K, Wong S, Hatcher S, Kaluzienski M, Yatham LN, Cipriani A, Gosling CJ, Carhart-Harris R, Tanuseputro P, Myran DT, Fabiano N, Moher D, Mayo LM, Nicholls SG, White T, Prisco M, Radua J, Vieta E, Ladha KS, Katz J, Veroniki AA, Solmi M

Corrigendum to "The role of the psychedelic experience in psilocybin treatment for treatment-resistant depression" [Journal of Affective Disorders, Volume 372 (2025), Pages 523-532].

Journal of affective disorders

Goodwin GM, Aaronson ST, Alvarez O, Carhart-Harris R, Chai-Rees J, Croal M, DeBattista C, Dunlop BW, Feifel D, Hellerstein DJ, Husain MI, Kelly JR, Kirlic N, Licht RW, Marwood L, Meyer TD, Mistry S, Nowakowska A, Pálenícek T, Repantis D, Schoevers RA, Simmons H, Somers M, Teoh E, Tsai J, Wahba M, Williams S, Young AH, Young MB, Zisook S, Malievskaia E

A Field-Wide Review and Analysis of Study Materials Used in Psilocybin Trials: Assessment of Two Decades of Research.

Psychedelic medicine (New Rochelle, N.Y.)

Yaden DB, Graziosi M, Owen AM, Agin-Liebes G, Aaronson ST, Allen KE, Barrett FS, Bogenschutz MP, Carhart-Harris R, Ching THW, Cosimano MP, Danforth A, Davis AK, Garcia-Romeu A, Griffiths R, Grob CS, Gründer G, Gukasyan N, Heinzerling KG, Hendricks PS, Holze F, Horton DM, Johnson MW, Kelmendi B, Knatz Peck S, Koslowski M, Liechti ME, Mertens LJ, Moreno FA, Nayak SM, Nicholas CR, Preller KH, Rieser NM, Ross S, Sergi K, Sloshower J, Smigielski L, Stenbæk DS, Vollenweider FX, Weiss B, Wolff M, Yaden ME

On Minimizing Risk and Harm in the Use of Psychedelics.

Psychiatric research and clinical practice

Evans J, Aixalà M, Anderson BT, Brennan W, Bremler R, Breeksema JJ, Burback L, Calder AE, Carhart-Harris RL, Cheung K, Devenot N, Gorman I, Gren J, Hendricks PS, Holoyda B, Jacobs E, Krecké J, Kruger DJ, Luke D, Majic T, McGuire AL, Mehtani NJ, Mathai DS, Nash K, Noorani T, Palitsky R, Robinson OC, Simonsson O, Stahre E, van Elk M, Yaden DB

Psilocybin desynchronizes the human brain.

Nature

Siegel JS, Subramanian S, Perry D, Kay BP, Gordon EM, Laumann TO, Reneau TR, Metcalf NV, Chacko RV, Gratton C, Horan C, Krimmel SR, Shimony JS, Schweiger JA, Wong DF, Bender DA, Scheidter KM, Whiting FI, Padawer-Curry JA, Shinohara RT, Chen Y, Moser J, Yacoub E, Nelson SM, Vizioli L, Fair DA, Lenze EJ, Carhart-Harris R, Raison CL, Raichle ME, Snyder AZ, Nicol GE, Dosenbach NUF

Human brain effects of DMT assessed via EEG-fMRI.

Proceedings of the National Academy of Sciences of the United States of America

Timmermann C, Roseman L, Haridas S, Rosas FE, Luan L, Kettner H, Martell J, Erritzoe D, Tagliazucchi E, Pallavicini C, Girn M, Alamia A, Leech R, Nutt DJ, Carhart-Harris RL

Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression.

The New England journal of medicine

Goodwin GM, Aaronson ST, Alvarez O, Arden PC, Baker A, Bennett JC, Bird C, Blom RE, Brennan C, Brusch D, Burke L, Campbell-Coker K, Carhart-Harris R, Cattell J, Daniel A, DeBattista C, Dunlop BW, Eisen K, Feifel D, Forbes M, Haumann HM, Hellerstein DJ, Hoppe AI, Husain MI, Jelen LA, Kamphuis J, Kawasaki J, Kelly JR, Key RE, Kishon R, Knatz Peck S, Knight G, Koolen MHB, Lean M, Licht RW, Maples-Keller JL, Mars J, Marwood L, McElhiney MC, Miller TL, Mirow A, Mistry S, Mletzko-Crowe T, Modlin LN, Nielsen RE, Nielson EM, Offerhaus SR, O'Keane V, Pálenícek T, Printz D, Rademaker MC, van Reemst A, Reinholdt F, Repantis D, Rucker J, Rudow S, Ruffell S, Rush AJ, Schoevers RA, Seynaeve M, Shao S, Soares JC, Somers M, Stansfield SC, Sterling D, Strockis A, Tsai J, Visser L, Wahba M, Williams S, Young AH, Ywema P, Zisook S, Malievskaia E

Altered Insula Connectivity under MDMA.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Walpola IC, Nest T, Roseman L, Erritzoe D, Feilding A, Nutt DJ, Carhart-Harris RL

Neural correlates of the LSD experience revealed by multimodal neuroimaging.

Proceedings of the National Academy of Sciences of the United States of America

Carhart-Harris RL, Muthukumaraswamy S, Roseman L, Kaelen M, Droog W, Murphy K, Tagliazucchi E, Schenberg EE, Nest T, Orban C, Leech R, Williams LT, Williams TM, Bolstridge M, Sessa B, McGonigle J, Sereno MI, Nichols D, Hellyer PJ, Hobden P, Evans J, Singh KD, Wise RG, Curran HV, Feilding A, Nutt DJ

The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity.

Biological psychiatry

Carhart-Harris RL, Murphy K, Leech R, Erritzoe D, Wall MB, Ferguson B, Williams LT, Roseman L, Brugger S, De Meer I, Tanner M, Tyacke R, Wolff K, Sethi A, Bloomfield MA, Williams TM, Bolstridge M, Stewart L, Morgan C, Newbould RD, Feilding A, Curran HV, Nutt DJ